Arrapha remained an important Assyrian city until the fall of the Assyrian empire between 615–599 BC.
After this it remained a part of the geo-political province of Assyria (Achaemenid Assyria, Athura, Seleucid Syria, Assyria (Roman province) and Assuristan) under various foreign empires, and between the 2nd century BC and 3rd century AD became the capital of the Neo-Assyrian state of Beth Garmai before this was conquered into the Sassanid empire and became a part of Assuristan.
The region became a part of the Akkadian empire (2335–2154 BC) which united all of the Akkadian and Sumerian speaking Mesopotamians under one rule.
After its collapse, the language isolate speaking Gutians, a pre-Iranic race from Ancient Iran, overran the region for a few decades, making Arrapha their capital, before being ejected from Mesopotamia by the Sumerians during the Neo-Sumerian Empire (2112–2004 BC).
The city remained a part of the Sassanid Empire until the Islamic conquest in the mid 7th century AD.